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Miles Morales' world has been shaken up lately, but nothing compares to what the mysterious Iron Spider and his new group of super villains are about to do. Sandman, Hobgoblin, the Spot, Electro and Bombshell (?!) have united...to make Miles' life a living hell! And unfortunately for those closest to our hero, it's not just his life that's going to get obliterated. Miles' friend Lana has been through so much and grown into a hero. But with Bombshell on the Sinister Six, things look set to blow up for her -- in a bad way! Can Spider-Man possibly save the day, or are the odds against him? Be there as Miles Morales faces his greatest challenge yet!