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Paul:           I asked Zuckerberg, actually, what question we could put on the Y Combinator application that would detect people like him. And he said, “When was the first time you realized things were broken and you wanted to fix them?

Interviews With the Masters

Robert Greene

THE RESULTS ARE very consistent. Drugs that raise insulin levels cause weight gain. Drugs that have no effect on insulin levels are weight neutral. Drugs that lower insulin levels cause weight loss. The effect on weight is independent of the effect on blood sugar. A recent study29 suggests that 75 percent of the weight-loss response in obesity is predicted by insulin levels. Not willpower. Not caloric intake. Not peer support or peer pressure. Not exercise. Just insulin. Insulin causes obesity—which means that insulin must be one of the major controllers of the body set weight. As insulin goes up, the body set weight goes up. The hypothalamus sends out hormonal signals to the body to gain weight. We become hungry and eat. If we deliberately restrict caloric intake, then our total energy expenditure will decrease. The result is still the same—weight gain. As the insightful Gary Taubes wrote in his book Why We Get Fat: And What to Do about It, “We do not get fat because we overeat. We overeat because we get fat.” And why do we get fat? We get fat because our body set weight thermostat is set too high. Why? Because our insulin levels are too high.

The Obesity Code

Jason Fung and Timothy Noakes

“In our model of misogi, there are only two rules,” said Elliott. “Rule number one is that it has to be really fucking hard. Rule number two is that you can’t die.” I understood the not-dying part, but asked him how he determines if something is hard enough. “We’re generally guided by the idea that you should have a fifty percent chance of success—if you do everything right,” he said. “So if you decided you wanted to run a twenty-five-mile trail, and you’re preparing by working up to a twenty-mile training run and doing thirty-five or forty miles a week of running…that’s not a misogi. Your chance of failure is too low. But if you’ve never run more than ten miles, think you could probably run fifteen, but are iffy on whether you could run twenty…then that twenty-five miles is probably a misogi.”

The Comfort Crisis

Michael Easter

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